The Side Effects of Dermaxx Painkiller

Dermaxx Side Effects:

The following can occur when the drug goes above a certain level in a dog's system.
The degree of damage and danger varies, but can include death.

-kidney damage and secondary effects on the heart.

-gastro-intestinal ulceration

-liver damage

In the case of the kidneys, NSAIDs (non-steroidal anti-inflammatory drug) can upset the body’s ability to regulate electrolytes such as sodium and potassium, leading to sky-rocketing increases in blood pressure and the kidneys themselves can be damaged leading to other problems. Dermaxx is frequently associated with high levels of BUN and Creatinine. Adverse event reports further suggest that Dermaxx can cause irreparable kidney damage. Many dogs continue to have abnormal blood values indicative of kidney damage long after they have stopped taking Dermaxx.

Although the gastro-intestinal effects of Dermaxx has been less than straightforward, but a review of reported adverse effects, including endoscopy and tissue biopsies indicates that Dermaxx can lead to massive gastric ulcerations. Signs and symptoms include vomiting, diarrhea and dark bloody stools.

Excessive levels of COX-2 inhibitors can be toxic to the liver as well as shown by the frequency of high levels of SGPT/ALT and ALK PHOS in the adverse event reports. In addition, the liver produces coagulation factors that are involved in wound healing, specifically the coagulation of blood. Bleeding caused by ulceration of the stomach cannot be stopped because the liver is not producing coagulation factors necessary to stop the bleeding. Exactly how Dermaxx damages the liver is not well understood. However, the damage is caused by toxic levels of the drug in the blood and that this is common sign of dogs who have reacted badly to Dermaxx.